ZFIN ID: ZDB-LAB-040720-1
Sudipto Roy Lab
PI/Director: Roy, Sudipto
Contact Person: Roy, Sudipto
Email: sudiptor@imcb.a-star.edu.sg
URL: http://www.imcb.a-star.edu.sg/research/research_group/development_biology/6000000107_article.html
Address: Institute of Molecular and Cell Biology Proteos, 61 Biopolis Drive, Singapore 138673 REPUBLIC OF SINGAPORE
Country: Singapore
Phone: 65 6586 9744
Fax: 65 6779 1117
Line Designation: sq

Show all 15 genomic features


Choksi, Semil P. Post-Doc Srinivas, B. P. Post-Doc Liew, Hoe Peng Graduate Student
Lee, Ban Chuan Research Staff Leong, Wan Ying Research Staff Ng, Teclise Research Staff
Tay, Shang Yew Research Staff

Truong, M.E., Bilekova, S., Choksi, S.P., Li, W., Bugaj, L.J., Xu, K., Reiter, J.F. (2021) Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Cell. 184(11):2911-2926.e18
Zhou, F., Rayamajhi, D., Ravi, V., Narasimhan, V., Chong, Y.L., Lu, H., Venkatesh, B., Roy, S. (2020) Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates. Developmental Biology. 465(2):168-177
Lu, H., Shagirova, A., Goggi, J.L., Yeo, H.L., Roy, S. (2020) Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine. Biology Open. 9(5):
Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
Lu, H., Anujan, P., Zhou, F., Zhang, Y., Chong, Y.L., Bingle, C.D., Roy, S. (2019) Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals. Development (Cambridge, England). 146(6):
Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
Chong, Y.L., Zhang, Y., Zhou, F., Roy, S. (2018) Distinct requirements of E2f4 versus E2f5 activity for multiciliated cell development in the zebrafish embryo. Developmental Biology. 443(2):165-172
Sigg, M.A., Menchen, T., Lee, C., Johnson, J., Jungnickel, M.K., Choksi, S.P., Garcia, G., Busengdal, H., Dougherty, G.W., Pennekamp, P., Werner, C., Rentzsch, F., Florman, H.M., Krogan, N., Wallingford, J.B., Omran, H., Reiter, J.F. (2017) Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Developmental Cell. 43:744-762.e11
Lu, H., Galeano, M.C.R., Ott, E., Kaeslin, G., Kausalya, P.J., Kramer, C., Ortiz-Brüchle, N., Hilger, N., Metzis, V., Hiersche, M., Tay, S.Y., Tunningley, R., Vij, S., Courtney, A.D., Whittle, B., Wühl, E., Vester, U., Hartleben, B., Neuber, S., Frank, V., Little, M.H., Epting, D., Papathanasiou, P., Perkins, A.C., Wright, G.D., Hunziker, W., Gee, H.Y., Otto, E.A., Zerres, K., Hildebrandt, F., Roy, S., Wicking, C., Bergmann, C. (2017) Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nature Genetics. 49:1025–1034
Zhang, W., Roy, S. (2017) Myomaker is required for the fusion of fast-twitch myocytes in the zebrafish embryo. Developmental Biology. 423(1):24-33
Zhang, W., Roy, S. (2016) The zebrafish fast myosin light chain mylpfa:H2B-GFP transgene is a useful tool for in vivo imaging of myocyte fusion in the vertebrate embryo. Gene expression patterns : GEP. 20(2):106-10
Leong, W.Y., Lim, Z.H., Korzh, V., Pietri, T., Goh, E.L. (2015) Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2. Frontiers in Cellular Neuroscience. 9:481
Zhou, F., Narasimhan, V., Shboul, M., Chong, Y.L., Reversade, B., Roy, S. (2015) Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program. Current biology : CB. 25(24):3267-73
Chua, J.S., Liew, H.P., Guo, L., Lane, D.P. (2015) Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish. Oncogene. 34(48):5933-41
Boyd, P.J., Cunliffe, V.T., Roy, S., Wood, J.D. (2015) Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open. 4(10):1336-43
Narasimhan, V., Hjeij, R., Vij, S., Loges, N.T., Wallmeier, J., Koerner-Rettberg, C., Werner, C., Thamilselvam, S.K., Boey, A., Choksi, S., Pennekamp, P., Roy, S., Omran, H. (2015) Mutations in CCDC11, Which Encodes a Coiled-coil Containing Ciliary Protein, Causes situs inversus Due to Dysmotility of Monocilia in the Left-Right Organizer. Human Mutation. 36(3):307-18
Lu, H., Toh, M.T., Narasimhan, V., Thamilselvam, S.K., Choksi, S.P., Roy, S. (2015) A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Developmental Biology. 397(2):225-36
Choksi, S.P., Babu, D., Lau, D., Yu, X., Roy, S. (2014) Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development (Cambridge, England). 141:3410-9
Tan, D.S., Haaland, B., Gan, J.M., Tham, S.C., Sinha, I., Tan, E.H., Lim, K.H., Takano, A., Krisna, S.S., Thu, M.M., Liew, H.P., Ullrich, A., Lim, W.T., and Chua, B.T. (2014) Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer. Molecular Cancer. 13(1):13
Guo, L., Liew, H.P., Camus, S., Goh, A.M., Chee, L.L., Lunny, D.P., Lane, E.B., and Lane, D.P. (2013) Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Oncogene. 32(34):4009-16
Irimia, M., Tena, J.J., Alexis, M., Fernandez-Miñan, A., Maeso, I., Bogdanovic, O., de la Calle-Mustienes, E., Roy, S.W., Gómez-Skarmeta, J.L., and Fraser, H.B. (2012) Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints. Genome research. 22(12):2356-2367
Vij, S., Rink, J.C., Ho, H.K., Babu, D., Eitel, M., Narasimhan, V., Tiku, V., Westbrook, J., Schierwater, B., and Roy, S. (2012) Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program. PLoS Genetics. 8(11):e1003019
Yu, X., Lau, D., Ng, C.P., and Roy, S. (2011) Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development (Cambridge, England). 138(3):487-494
Rochlin, K., Yu, S., Roy, S., and Baylies, M.K. (2010) Myoblast fusion: When it takes more to make one. Developmental Biology. 341(1):66-83
Tay, S.Y., Yu, X., Wong, K.N., Panse, P., Ng, C.P., and Roy, S. (2010) The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 239(2):527-534
Liew, H.P., Choksi, S.P., Wong, K.N., and Roy, S. (2008) Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimp1. Developmental Biology. 324(2):226-235
Yu, X., Ng, C.P., Habacher, H., and Roy, S. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics. 40(12):1445-1453
Bessarab, D.A., Chong, S.W., Srinivas, B.P., and Korzh, V. (2008) Six1a is required for the onset of fast muscle differentiation in zebrafish. Developmental Biology. 323(2):216-228
Srinivas, B.P., Woo, J., Leong, W.Y., and Roy, S. (2007) A conserved molecular pathway mediates myoblast fusion in insects and vertebrates. Nature Genetics. 39(6):781-786
Roy, S. (2007) Genetic analysis of the vertebrate hedgehog-signaling pathway using muscle cell fate specification in the zebrafish embryo. Methods in molecular biology (Clifton, N.J.). 397(1):55-66
Lee, B.C., and Roy, S. (2006) Blimp-1 is an essential component of the genetic program controlling development of the pectoral limb bud. Developmental Biology. 300(2):623-634
Xu, J., Srinivas, B.P., Tay, S.Y., Mak, A., Yu, X., Lee, S.G., Yang, H., Govindarajan, K.R., Leong, B., Bourque, G., Mathavan, S., and Roy, S. (2006) Genome-wide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development. Genetics. 174(2):735-752
Tay, S.Y., Ingham, P.W., and Roy, S. (2005) A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development (Cambridge, England). 132(4):625-634
Roy, S., and Ng, T. (2004) Blimp-1 specifies neural crest and sensory neuron progenitors in the zebrafish embryo. Current biology : CB. 14(19):1772-1777
Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. (2004) iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes & Development. 18(13):1565-1576
Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F., and Ingham, P.W. (2004) Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Developmental Biology. 269(2):381-392
Baxendale, S., Davison, C., Muxworthy, C., Wolff, C., Ingham, P.W., and Roy, S. (2004) The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling. Nature Genetics. 36(1):88-93
Wolff, C., Roy, S., and Ingham, P.W. (2003) Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Current biology : CB. 13(14):1169-1181
Roy, S., Qiao, T., Wolff, C., and Ingham, P.W. (2001) Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Current biology : CB. 11(17):1358-1363
Roy, S., Wolff, C., and Ingham, P.W. (2001) The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo. Genes & Development. 15(12):1563-1576
Lewis, K.E., Currie, P.D., Roy, S., Schauerte, H., Haffter, P., and Ingham, P.W. (1999) Control of muscle cell-type specification in the zebrafish embryo by hedgehog signalling. Developmental Biology. 216(2):469-480
Roy, S. (1994) Development of the zebrafish nervous system: Mechanisms of cellfate specification and axonal pathfinding in the central nervous system and periphery. Curr. Sci. Bangalore. 66(9):629-633