ZFIN Lab: Lepage Lab

ZFIN ID: ZDB-LAB-021118-1

ZFIN ID: ZDB-LAB-021118-1

Lepage Lab

PI/Director:	Lepage, Thierry
Contact Person:	Lepage, Thierry
Email:	lepage@obs-vlfr.fr
URL:	http://biodev.obs-vlfr.fr
Address:	Observatoire Océanologique Université Pierre et Marie Curie Centre National de la Recherche Scientifique Villefranche-sur-Mer, 06230 France
Country:	France
Phone:	(33) 493-76-38-70
Fax:	(33) 493-76-37-92
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our lab is located at the Marine Station of Villefranche-sur-Mer (close to Nice). We are interested by various aspects of early development such as the processes of germ layer and axis specification. We use both zebrafish and sea urchin embryos as models. Our studies in zebrafish concern the cellular and molecular mechanisms regulating endoderm and mesoderm formation. We have identified several genes expressed early in response to Nodal signalling and try to understand their role in cell fate specification. We are also interested in development of the sea urchin embryo. Our studies on this embryo concern the processes of dorsal-ventral axis specification, epithelial mesenchyme transition and establishment of left-right asymmetry.

LAB MEMBERS

Duboc, Veronique Graduate Student	Poulain, Morgane Graduate Student	Rottinger, Eric Graduate Student
Besnardeau, Lydia Technical Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Saraswathy, V.M., Kurup, A.J., Sharma, P., Polès, S., Poulain, M., Fürthauer, M. (2022) The E3 Ubiquitin Ligase Mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. eLIFE. 11:

Chenevert, J., Roca, M., Besnardeau, L., Ruggiero, A., Nabi, D., McDougall, A., Copley, R.R., Christians, E., Castagnetti, S. (2020) The Spindle Assembly Checkpoint Functions during Early Development in Non-Chordate Embryos. Cells. 9(5):

Lekk, I., Duboc, V., Faro, A., Nicolaou, S., Blader, P., Wilson, S.W. (2019) Sox1a mediates the ability of the parapineal to impart habenular left-right asymmetry. eLIFE. 8:

Mamińska, A., Bartosik, A., Banach-Orłowska, M., Pilecka, I., Jastrzębski, K., Zdżalik-Bielecka, D., Castanon, I., Poulain, M., Neyen, C., Wolińska-Nizioł, L., Toruń, A., Szymańska, E., Kowalczyk, A., Piwocka, K., Simonsen, A., Stenmark, H., Fürthauer, M., González-Gaitán, M., Miaczynska, M. (2016) ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors. Science signaling. 9(411):ra8

Poulain, M., and Ober, E.A. (2011) Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Development (Cambridge, England). 138(16):3557-68

Poulain, M., Fürthauer, M., Thisse, B., Thisse, C., and Lepage, T. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development (Cambridge, England). 133(11):2189-2200

Poulain, M. and Lepage, T. (2002) Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish. Development (Cambridge, England). 129(21):4901-4914

Faucourt, M., Houliston, E., Besnardeau, L., Kimelman, D., and Lepage, T. (2001) The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. Developmental Biology. 229(2):287-306

Lister, J.A., Robertson, C.P., Lepage, T., Johnson, S.L., and Raible, D.W. (1999) nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate. Development (Cambridge, England). 126(17):3757-3767