ZFIN Lab: Izpisúa Belmonte Lab

ZFIN ID: ZDB-LAB-020725-2

Izpisúa Belmonte Lab

PI/Director:	Izpisúa Belmonte, Juan Carlos
Contact Person:	Schwarz, May
Email:	mchu@salk.edu
URL:	http://belmonte.salk.edu/0intro.htm
Address:	Gene Expression Laboratories The Salk Institute for Biological Studies P.O. Box 85800 10010 North Torrey Pines Road San Diego, CA 92186-5800 USA
Country:	United States
Phone:	(858) 453-4100 ext. 1167
Fax:	(858) 453-2573
Line Designation:	be

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 9 genomic features

STATEMENT OF RESEARCH INTERESTS

Our primary focus of research is to understand how the vertebrate embryo develops. The main research topics are the molecular and cellular mechanisms by which (a) the left-right asymmetrical disposition of the internal organs is established, (b) the vertebrate limb develops.

LAB MEMBERS

Dubova, Ilir, M.D. Post-Doc	Raya, Marina Post-Doc	Rodriguez-Esteban, Concepcion Post-Doc
Ribeiro, Ines Graduate Student	Callol Massot, Carles Research Staff	Schwarz, May Administrative Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Alday, A., Alonso, H., Gallego, M., Urrutia, J., Letamendia, A., Callol, C., Casis, O. (2014) Ionic channels underlying the ventricular action potential in zebrafish embryo. Pharmacological research. 84C:26-31

Jopling, C., Suñè, G., Faucherre, A., Fabregat, C., and Izpisúa Belmonte, J.C. (2012) Hypoxia Induces Myocardial Regeneration in Zebrafish. Circulation. 126(25):3017-3027

Cavaco Rodrigues, A.M., Christen, B., Marti, M., and Izpisua Belmonte, J.C. (2012) Skeletal muscle regeneration in Xenopus tadpoles and zebrafish larvae. BMC Developmental Biology. 12(1):9

Letamendia, A., Quevedo, C., Ibarbia, I., Virto, J.M., Holgado, O., Diez, M., Izpisúa Belmonte, J.C., and Callol-Massot, C. (2012) Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One. 7(5):e36690

Eguiara, A., Holgado, O., Beloqui, I., Abalde, L., Sanchez, Y., Callol, C., and Martin, A.G. (2011) Xenografts in zebrafish embryos as a rapid functional assay for breast cancer stem-like cell identification. Cell cycle (Georgetown, Tex.). 10(21):3751-3757

Callol, C., Letamendia, A., Holgado, O., Diez, M. (2010) Evaluation of zebrafish as a model to predict human hepatotoxicity. Toxicology letters. 196:S214

Sleep, E., Boué, S., Jopling, C., Raya, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Transcriptomics approach to investigate zebrafish heart regeneration. Journal of cardiovascular medicine (Hagerstown, Md.). 11(5):369-380

Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., and Izpisúa Belmonte, J.C. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 464(7288):606-609

Christen, B., Robles, V., Raya, M., Paramonov, I., and Izpisúa Belmonte, J.C. (2010) Regeneration and reprogramming compared. BMC Biology. 8:5

Stewart, S., Tsun, Z.Y., and Izpisúa Belmonte, J.C. (2009) A histone demethylase is necessary for regeneration in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(47):19889-19894

Kan, N.G., Junghans, D., and Izpisúa Belmonte, J.C. (2009) Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(10):3516-3525

Jopling, C., and Izpisúa Belmonte, J.C. (2009) Cilia-Where Two Wnts Collide. Zebrafish. 6(1):15-19

Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Antos, C., Rodríguez Esteban, C., Nüsslein-Volhard, C., and Izpisúa Belmonte, J.C. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. Developmental Biology. 327(1):177-190

Fink, M., Callol, C., Chu, A., Ruiz-Lozano, P., Izpisúa Belmonte, J.C., Giles, W., Bodmer, R., and Ocorr, K. (2009) A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques. 46(2):101-113

Stubbs, J.L., Oishi, I., Izpisúa Belmonte, J.C., and Kintner, C. (2008) The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nature Genetics. 40(12):1454-1460

Kang, J.S., Kawakami, Y., Bekku, Y., Ninomiya, Y., Izpisúa Belmonte, J.C., and Oohashi, T. (2008) Molecular Cloning and Developmental Expression of a Hyaluronan and Proteoglycan Link Protein Gene, crtl1/hapln1, in Zebrafish. Zoological science. 25(9):912-918

Raya, A., and Izpisúa Belmonte, J.C. (2008) Insights into the establishment of left-right asymmetries in vertebrates. Birth defects research. Part C, Embryo today : reviews. 84(2):81-94

Moreno, T.A., Jappelli, R., Izpisúa Belmonte, J.C., and Kintner, C. (2008) Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning. Developmental Biology. 315(2):317-330

Stewart, S., Rojas-Muñoz, A., and Izpisúa Belmonte, J.C. (2007) Bioelectricity and epimorphic regeneration. BioEssays : news and reviews in molecular, cellular and developmental biology. 29(11):1133-1137

Ribeiro, I., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., and Izpisua Belmonte, J.C. (2007) Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling. PLoS One. 2(1):e398

Matsui, T., Raya, A., Callol-Massot, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2007) miles-apart-Mediated regulation of cell-fibronectin interaction and myocardial migration in zebrafish. Nature clinical practice. Cardiovascular medicine. 4(1):S77-S82

Kawakami, Y., Rodriguez Esteban, C., Raya, M., Kawakami, H., Marti, M., Dubova, I., and Izpisúa Belmonte, J.C. (2006) Wnt/beta-catenin signaling regulates vertebrate limb regeneration. Genes & Development. 20(23):3232-3237

Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., and Izpisúa Belmonte, J.C. (2006) Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nature Genetics. 38(11):1316-1322

Weninger, W.J., Geyer, S.H., Mohun, T.J., Rasskin-Gutman, D., Matsui, T., Ribeiro, I., Costa, L.D., Izpisúa Belmonte, J.C., and Muller, G.B. (2006) High-resolution episcopic microscopy: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology. Anatomy and embryology. 211(3):213-221

Raya, A., and Izpisúa Belmonte, J.C. (2006) Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration. Nature reviews. Genetics. 7(4):283-293

Luesch, H., Chanda, S.K., Raya, R.M., Dejesus, P.D., Orth, A.P., Walker, J.R., Izpisúa Belmonte, J.C., and Schultz, P.G. (2006) A functional genomics approach to the mode of action of apratoxin A. Nature Chemical Biology. 2(3):158-167

Correa, R.G., Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C., and Verma, I.M. (2005) Zebrafish IkappaB Kinase 1 Negatively Regulates NF-kappaB Activity. Current biology : CB. 15(14):1291-1295

Kawakami, Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2005) Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature. 435(7039):165-171

Matsui, T., Raya, A., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodriguez-Esteban, C., Izpisúa Belmonte, J.C. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes & Development. 19(1):164-175

Kawakami, Y., Esteban, C.R., Matsui, T., Rodriguez-Leon, J., Kato, S., and Izpisúa Belmonte, J.C. (2004) Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Development (Cambridge, England). 131(19):4763-4774

Raya, A., and Izpisúa Belmonte, J.C. (2004) Sequential transfer of left-right information during vertebrate embryo development. Current opinion in genetics & development. 14(5):575-581

Correa, R.G., Tergaonkar, V., Ng, J.K., Dubova, I., Izpisúa Belmonte, J.C., and Verma, I.M. (2004) Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Molecular and cellular biology. 24(12):5257-5268

Huang, Q., Raya, A., DeJesus, P., Chao, S.H., Quon, K.C., Caldwell, J.S., Chanda, S.K., Izpisúa Belmonte, J.C., and Schultz, P.G. (2004) Identification of p53 regulators by genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 101(10):3456-3461

Raya, A., Consiglio, A., Kawakami, Y., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2004) The zebrafish as a model of heart regeneration. Cloning and stem cells. 6(4):345-351

Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisúa Belmonte, J.C., and De La Pompa, J.L. (2004) Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes & Development. 18(1):99-115

Raya, A., Koth, C.M., Büscher, D., Kawakami, Y., Itoh, T., Raya, R.M., Sternick, G., Tsai, H.J., Rodriguez-Esteban, C., and Izpisúa Belmonte, J.C. (2003) Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. (Suppl. 1) 100:11889-11895

Kawakami, Y., Rodriguez-Leon, J., Koth, C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez-Esteban, C., Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H., and Izpisúa Belmonte, J.C. (2003) MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature cell biology. 5(6):513-519

Raya, A., Kawakami, Y., Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M., Raya, R.M., Dubova, I., Bessa, J.G., de la Pompa, J.L., and Izpisúa Belmonte, J.C. (2003) Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes & Development. 17(10):1213-1218

Ng, J.K., Kawakami, Y., Büscher, D., Raya, A., Itoh, T., Koth, C.M., Rodriguez-Esteban, C., Rodríguez-León, J., Garrity, D.M., Fishman, M.C., and Izpisúa Belmonte, J.C. (2002) The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development (Cambridge, England). 129(22):5161-5170

Liang, J.O., Etheridge, A., Hantsoo, L., Rubinstein, A.L., Nowak, S.J., Izpisúa Belmonte, J.C., and Halpern, M.E. (2000) Asymmetric Nodal signaling in the zebrafish diencephalon positions the pineal organ. Development (Cambridge, England). 127(23):5101-5112

Tamura, K., Yonei-Tamura, S., and Belmonte, J.C. (1999) Molecular basis of left-right asymmetry. Development, growth & differentiation. 41(6):645-656

Tsukui, T., Capdevila, J., Tamura, K., Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallon, J., Chandraratna, R.A., Chien, K., Blumberg, B., Evans, R.M., and Belmonte, J.C. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proceedings of the National Academy of Sciences of the United States of America. 96(20):11376-11381

Tamura, K., Yonei-Tamura, S., and Belmonte, J.C. (1999) Differential expression of Tbx4 and Tbx5 in zebrafish fin buds. Mechanisms of Development. 87(1-2):181-184

Yonei-Tamura, S., Tamura, K., Tsukui, T., and Izpisúa Belmonte, J.C. (1999) Spatially and temporally-restricted expression of two T-box genes during zebrafish embryogenesis. Mechanisms of Development. 80(2):219-221

van der, Hoeven, F., Sordino, P., Fraudeau, N., Izpisúa Belmonte, J.C., and Duboule, D. (1996) Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex. Mechanisms of Development. 54(1):9-21

Fjose, A., Izpisúa Belmonte, J.C., Fromental-Ramain, C., and Duboule, D. (1994) Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development. Development (Cambridge, England). 120:71-81