ZFIN Lab: Laudet Lab

ZFIN ID: ZDB-LAB-010213-1

Laudet Lab

PI/Director:	Laudet, Vincent
Contact Person:	Laudet, Vincent
Email:	Vincent.Laudet@ens-lyon.fr
URL:
Address:	UMR 5665 du CNRS Ecole Normale Supérieure de Lyon 46 Allée d'Italie Cedex 07 Lyon, 69364 France
Country:	France
Phone:	33-4-7272-8190
Fax:	33-4-7272-8080
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our lab is studying the role of nuclear hormone receptors in developpement and evolution. We focuss on 4 main topics : (i) role of the estrogen receptors (ER) and the estrogen related receptors (ERR) which are orphan receptors in development ; (ii) the study of circadian rhythm using the zebrafish as a model system with a particular emphasis on the role of the orphan receptors Rev-erb and ROR ; (iii) the importance of gene duplications in vertebrate evolution, using the nuclear hormone receptors are markers and (iv) the evolution of thyroid hormone regulation of metamorphosis in vertebrates.

LAB MEMBERS

Escriva, Hector Post-Doc	Horard, Béatrice Post-Doc	Thénot, Sandrine Post-Doc
Bardet, Pierre-Luc Graduate Student	Bertrand, Stéphanie Graduate Student	Marchand, Oriane Graduate Student
Triqueneaux, Gérard Research Staff	Canaple, Laurence	Nassouri, Lamia
Schubert, Michael

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Gil-Gálvez, A., Jiménez-Gancedo, S., Pérez-Posada, A., Franke, M., Acemel, R.D., Lin, C.Y., Chou, C., Su, Y.H., Yu, J.K., Bertrand, S., Schubert, M., Escrivá, H., Tena, J.J., Gómez-Skarmeta, J.L. (2022) Gain of gene regulatory network interconnectivity at the origin of vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 119:e2114802119

Salis, P., Roux, N., Huang, D., Marcionetti, A., Mouginot, P., Reynaud, M., Salles, O., Salamin, N., Pujol, B., Parichy, D.M., Planes, S., Laudet, V. (2021) Thyroid hormones regulate the formation and environmental plasticity of white bars in clownfishes. Proceedings of the National Academy of Sciences of the United States of America. 118(23):

Cantaut-Belarif, Y., Orts Del'Immagine, A., Penru, M., Pézeron, G., Wyart, C., Bardet, P.L. (2020) Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development. eLIFE. 9:

Sadier, A., Jackman, W.R., Laudet, V., Gibert, Y. (2020) The Vertebrate Tooth Row: Is It Initiated by a Single Organizing Tooth?. BioEssays : news and reviews in molecular, cellular and developmental biology. 42(6):e1900229

Orts-Del'Immagine, A., Cantaut-Belarif, Y., Thouvenin, O., Roussel, J., Baskaran, A., Langui, D., Koëth, F., Bivas, P., Lejeune, F.X., Bardet, P.L., Wyart, C. (2020) Sensory Neurons Contacting the Cerebrospinal Fluid Require the Reissner Fiber to Detect Spinal Curvature In Vivo. Current biology : CB. 30(5):827-839.e4

Thouvenin, O., Keiser, L., Cantaut-Belarif, Y., Carbo-Tano, M., Verweij, F., Jurisch-Yaksi, N., Bardet, P.L., van Niel, G., Gallaire, F., Wyart, C. (2020) Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLIFE. 9:

Gibert, Y., Samarut, E., Ellis, M.K., Jackman, W.R., Laudet, V. (2019) The first formed tooth serves as a signalling centre to induce the formation of the dental row in zebrafish. Proceedings. Biological sciences. 286:20190401

Desban, L., Prendergast, A., Roussel, J., Rosello, M., Geny, D., Wyart, C., Bardet, P.L. (2019) Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology. 17:e3000235

Salis, P., Lorin, T., Lewis, V., Rey, C., Marcionetti, A., Escande, M.L., Roux, N., Besseau, L., Salamin, N., Sémon, M., Parichy, D., Volff, J.N., Laudet, V. (2019) Developmental and comparative transcriptomic identification of iridophore contribution to white barring in clownfish. Pigment cell & melanoma research. 32(3):391-402

Marlétaz, F., Firbas, P.N., Maeso, I., Tena, J.J., Bogdanovic, O., Perry, M., Wyatt, C.D.R., de la Calle-Mustienes, E., Bertrand, S., Burguera, D., Acemel, R.D., van Heeringen, S.J., Naranjo, S., Herrera-Ubeda, C., Skvortsova, K., Jimenez-Gancedo, S., Aldea, D., Marquez, Y., Buono, L., Kozmikova, I., Permanyer, J., Louis, A., Albuixech-Crespo, B., Le Petillon, Y., Leon, A., Subirana, L., Balwierz, P.J., Duckett, P.E., Farahani, E., Aury, J.M., Mangenot, S., Wincker, P., Albalat, R., Benito-Gutiérrez, È., Cañestro, C., Castro, F., D'Aniello, S., Ferrier, D.E.K., Huang, S., Laudet, V., Marais, G.A.B., Pontarotti, P., Schubert, M., Seitz, H., Somorjai, I., Takahashi, T., Mirabeau, O., Xu, A., Yu, J.K., Carninci, P., Martinez-Morales, J.R., Crollius, H.R., Kozmik, Z., Weirauch, M.T., Garcia-Fernàndez, J., Lister, R., Lenhard, B., Holland, P.W.H., Escriva, H., Gómez-Skarmeta, J.L., Irimia, M. (2018) Amphioxus functional genomics and the origins of vertebrate gene regulation. Nature. 564:64-70

Sternberg, J.R., Prendergast, A.E., Brosse, L., Cantaut-Belarif, Y., Thouvenin, O., Orts-Del'Immagine, A., Castillo, L., Djenoune, L., Kurisu, S., McDearmid, J.R., Bardet, P.L., Boccara, C., Okamoto, H., Delmas, P., Wyart, C. (2018) Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature communications. 9:3804

Cantaut-Belarif, Y., Sternberg, J.R., Thouvenin, O., Wyart, C., Bardet, P.L. (2018) The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis. Current biology : CB. 28(15):2479-2486.e4

Cosse-Etchepare, C., Gervi, I., Buisson, I., Formery, L., Schubert, M., Riou, J.F., Umbhauer, M., Le Bouffant, R. (2018) Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. The International journal of developmental biology. 62:325-333

Djenoune, L., Desban, L., Gomez, J., Sternberg, J.R., Prendergast, A., Langui, D., Quan, F.B., Marnas, H., Auer, T.O., Rio, J.P., Del Bene, F., Bardet, P.L., Wyart, C. (2017) The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports. 7:719

Holzer, G., Morishita, Y., Fini, J.B., Lorin, T., Gillet, B., Hughes, S., Tohmé, M., Deléage, G., Demeneix, B., Arvan, P., Laudet, V. (2016) Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates. The Journal of biological chemistry. 291(32):16553-66

Li, L., Bonneton, F., Tohme, M., Bernard, L., Chen, X.Y., Laudet, V. (2016) In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. PLoS One. 11:e0149497

Sadier, A., Lambert, E., Chevret, P., Décimo, D., Sémon, M., Tohmé, M., Ruggiero, F., Ohlmann, T., Pantalacci, S., Laudet, V. (2015) Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD. BMC Evolutionary Biology. 15:129

Gibert, Y., Samarut, E., Pasco-Viel, E., Bernard, L., Borday-Birraux, V., Sadier, A., Labbé, C., Viriot, L., Laudet, V. (2015) Altered retinoic acid signalling underpins dentition evolution. Proceedings. Biological sciences. 282(1802)

Samarut, E., Fraher, D., Laudet, V., Gibert, Y. (2015) ZebRA: An overview of retinoic acid signaling during zebrafish development. Biochimica et biophysica acta. Gene regulatory mechanisms. 1849(2):73-83

Tohmé, M., Prud'homme, S.M., Boulahtouf, A., Samarut, E., Brunet, F., Bernard, L., Bourguet, W., Gibert, Y., Balaguer, P., Laudet, V. (2014) Estrogen-related receptor γ is an in vivo receptor of bisphenol A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(7):3124-3133

Riu, A., McCollum, C.W., Pinto, C.L., Grimaldi, M., Hillenweck, A., Perdu, E., Zalko, D., Bernard, L., Laudet, V., Balaguer, P., Bondesson, M., Gustafsson, J.A. (2014) Halogenated Bisphenol-A Analogs Act as Obesogens in Zebrafish Larvae (Danio rerio). Toxicological sciences : an official journal of the Society of Toxicology. 139:48-58

Samarut, E., Gaudin, C., Hughes, S., Gillet, B., de Bernard, S., Jouve, P.E., Buffat, L., Allot, A., Lecompte, O., Berekelya, L., Rochette-Egly, C., and Laudet, V. (2014) Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo. Molecular endocrinology (Baltimore, Md.). 28(2):260-272

Seritrakul, P., Samarut, E., Lama, T.T., Gibert, Y., Laudet, V., and Jackman, W.R. (2012) Retinoic acid expands the evolutionarily reduced dentition of zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(12):5014-5024

Baas, D., Caussanel-Boude, S., Guiraud, A., Calhabeu, F., Delaune-Henry, E., Pilot, F., Chopin, E., Machuca-Gayet, I., Vernay, A., Bertrand, S., Rual, J.F., Jurdic, P., Hill, D.E., Vidal, M., Schaeffer, L., and Goillot, E. (2012) CKIP-1 regulates mammalian and zebrafish myoblast fusion. Journal of Cell Science. 125(16):3790-3800

Nishio, S.I., Gibert, Y., Berekelya, L., Bernard, L., Brunet, F., Guillot, E., Le Bail, J.C., Sánchez, J.A., Galzin, A.M., Triqueneaux, G., and Laudet, V. (2012) Fasting Induces CART Down-Regulation in the Zebrafish Nervous System in a Cannabinoid Receptor 1-Dependent Manner. Molecular endocrinology (Baltimore, Md.). 26(8):1316-1326

Lambert, E., Coissieux, M.M., Laudet, V., and Mehlen, P. (2012) Netrin-4 acts as a pro-angiogenic factor during zebrafish development. The Journal of biological chemistry. 287(6):3987-3999

Koop, D., Holland, L.Z., Setiamarga, D., Schubert, M., and Holland, N.D. (2011) Tail regression induced by elevated retinoic acid signaling in amphioxus larvae occurs by tissue remodeling, not cell death. Evolution & development. 13(5):427-435

Samarut, E., Amal, I., Markov, G.V., Stote, R., Dejaegere, A., Laudet, V., and Rochette-Egly, C. (2011) Evolution of Nuclear Retinoic Acid Receptor Alpha (RARα) Phosphorylation Sites. Serine Gain Provides Fine-Tuned Regulation. Mol. Biol. Evol.. 28(7):2125-37

Gibert, Y., Sassi-Messai, S., Fini, J.B., Bernard, L., Zalko, D., Cravedi, J.P., Balaguer, P., Andersson-Lendahl, M., Demeneix, B., and Laudet, V. (2011) Bisphenol A induces otolith malformations during vertebrate embryogenesis. BMC Developmental Biology. 11(1):4

Guenebeaud, C., Goldschneider, D., Castets, M., Guix, C., Chazot, G., Delloye-Bourgeois, C., Eisenberg-Lerner, A., Shohat, G., Zhang, M., Laudet, V., Kimchi, A., Bernet, A., and Mehlen, P. (2010) The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Molecular Cell. 40(6):863-876

Gibert, Y., Bernard, L., Debiais-Thibaud, M., Bourrat, F., Joly, J.S., Pottin, K., Meyer, A., Retaux, S., Stock, D.W., Jackman, W.R., Seritrakul, P., Begemann, G., and Laudet, V. (2010) Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(9):3298-3309

Dos Santos, S., Bardet, C., Bertrand, S., Escriva, H., Habert, D., and Querat, B. (2009) Distinct expression patterns of glycoprotein hormone-alpha2 and -beta5 in a basal chordate suggest independent developmental functions. Endocrinology. 150(8):3815-3822

Castets, M., Coissieux, M.M., Delloye-Bourgeois, C., Bernard, L., Delcros, J.G., Bernet, A., Laudet, V., and Mehlen, P. (2009) Inhibition of Endothelial Cell Apoptosis by Netrin-1 during Angiogenesis. Developmental Cell. 16(4):614-620

Sassi-Messai, S., Gibert, Y., Bernard, L., Nishio, S., Ferri Lagneau, K.F., Molina, J., Andersson-Lendahl, M., Benoit, G., Balaguer, P., and Laudet, V. (2009) The phytoestrogen genistein affects zebrafish development through two different pathways. PLoS One. 4(3):e4935

Douard, V., Brunet, F., Boussau, B., Ahrens, I., Vlaeminck-Guillem, V., Haendler, B., Laudet, V., and Guiguen, Y. (2008) The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?. BMC Evolutionary Biology. 8:336

Nishio, S.I., Gibert, Y., Bernard, L., Brunet, F., Triqueneaux, G., and Laudet, V. (2008) Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(6):1682-1690

Canaple, L., Beuf, O., Armenean, M., Hasserodt, J., Samarut, J., and Janier, M. (2008) Fast screening of paramagnetic molecules in zebrafish embryos by MRI. NMR in Biomedicine. 21(2):129-137

Nishio, S.I., Kakizawa, T., Chatelain, G., Triqueneaux, G., Brunet, F., Rambaud, J., Lamonerie, T., and Laudet, V. (2008) OTX5 regulates pineal expression of the zebrafish REV-ERBalpha through a new DNA binding site. Molecular endocrinology (Baltimore, Md.). 22(1):23-32

Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188

Kakizawa, T., Nishio, S., Triqueneaux, G., Bertrand, S., Rambaud, J., and Laudet, V. (2007) Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor gene Rev-erbalpha. Journal of molecular endocrinology. 38(5):555-568

Brunet, F.G., Crollius, H.R., Paris, M., Aury, J.M., Gibert, P., Jaillon, O., Laudet, V., and Robinson-Rechavi, M. (2006) Gene Loss and Evolutionary Rates Following Whole Genome Duplication in Teleost Fishes. Mol. Biol. Evol.. 23(9):1808-1816

Bardet, P.L., Horard, B., Laudet, V., and Vanacker, J.M. (2005) The ERRalpha orphan nuclear receptor controls morphogenetic movements during zebrafish gastrulation. Developmental Biology. 281(1):102-111

Bardet, P.L., Schubert, M., Horard, B., Holland, L.Z., Laudet, V., Holland, N.D., and Vanacker, J.M. (2005) Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition. Evolution & development. 7(3):223-233

Triqueneaux, G., Thenot, S., Kakizawa, T., Antoch, M.P., Safi, R., Takahashi, J.S., Delaunay, F., and Laudet, V. (2004) The orphan receptor Rev-erb{alpha} gene is a target of the circadian clock pacemaker. Journal of molecular endocrinology. 33(3):585-608

Gauchat, D., Escriva, H., Miljkovic-Licina, M., Chera, S., Langlois, M.C., Begue, A., Laudet, V., and Galliot, B. (2004) The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates. Developmental Biology. 275(1):104-123

Bertrand, S., Brunet, F.G., Escriva, H., Parmentier, G., Laudet, V., and Robinson-Rechavi, M. (2004) Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems. Mol. Biol. Evol.. 21(10):1923-1937

Bardet, P.L., Obrecht-Pflumio, S., Thisse, C., Laudet, V., Thisse, B., and Vanacker, J.M. (2004) Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish. Development genes and evolution. 214(5):240-249

Bertrand, S., Pinte, S., Stankovic-Valentin, N., Deltour-Balerdi, S., Guerardel, C., Begue, A., and Laudet, V., and Leprince, D. (2004) Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1. BBA Gene Structure and Expression. 1678(1):57-66

Delaunay, F., Thisse, C., Thisse, B., and Laudet, V. (2003) Differential regulation of Period 2 and Period 3 expression during development of the zebrafish circadian clock. Gene expression patterns : GEP. 3(3):319-324

Escriva Garcia, H., Laudet, V., and Robinson-Rechavi, M. (2003) Nuclear receptors are markers of animal genome evolution. Journal of structural and functional genomics. 3(1-4):177-184

Bardet, P.-L., Horard, B., Robinson-Rechavi, M., Laudet, V., and Vanacker, J.-M. (2002) Characterization of oestrogen receptors in zebrafish (Danio rerio). Journal of molecular endocrinology. 28(3):153-163

Menuet, A., Pellegrini, E., Anglade, I., Blaise, O., Laudet, V., Kah, O., and Pakdel, F. (2002) Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions. Biology of reproduction. 66(6):1881-1892

Robinson-Rechavi, M., Marchand, O., Escriva, H., and Laudet, V. (2001) An ancestral whole-genome duplication may not have been responsible for the abundance of duplicated fish genes. Current biology : CB. 11(12):R458-R459

Robinson-Rechavi, M., Marchand, O., Escriva, H., Bardet, P.L., Zelus, D., Hughes, S., and Laudet, V. (2001) Euteleost fish genomes are characterized by expansion of gene families. Genome research. 11(5):781-788

Robinson-Rechavi, M., and Laudet, V. (2001) Evolutionary rates of duplicate genes in fish and mammals. Mol. Biol. Evol.. 18(4):681-683

Marchand, O., Safi, R., Escriva, H., van Rompaey, E., Prunet, P., and Laudet, V. (2001) Molecular cloning and characterization of thyroid hormone receptors in teleost fish. Journal of molecular endocrinology. 26(1):51-65

Thisse, B., Thisse, C., and Laudet, V. (2001) Inherited circadian clock in zebrafish: the mother and her clock. Médecine Sciences. 17(3):365-368

Delaunay, F., Thisse, C., Marchand, O., Laudet, V., and Thisse, B. (2000) An inherited functional circadian clock in zebrafish embryos. Science (New York, N.Y.). 289(5477):297-300

Schubert, M., Holland, L.Z., Panopoulou, G.D., Lehrach, H., and Holland, N.D. (2000) Characterization of amphioxus AmphiWnt8: insights into the evolution of patterning of the embryonic dorsoventral axis. Evolution & development. 2(2):85-92

Escriva, H., Safi, R., Hanni, C., Langlois, M.C., Saumitou-Laprade, P., Stehelin, D., Capron, A., Pierce, R., and Laudet, V. (1997) Ligand binding was acquired during evolution of nuclear receptors. Proceedings of the National Academy of Sciences of the United States of America. 94(13):6803-6808