ZFIN Lab: Schachner Lab

ZFIN ID: ZDB-LAB-010209-1

Schachner Lab

PI/Director:	Schachner, Melitta
Contact Person:	Schachner, Melitta
Email:	melitta.schachner@zmnh.uni-hamburg.de
URL:	http://www.zmnh.uni-hamburg.de/schachner/
Address:	Zentrum für Molekulare Neurobiologie Institut für Biosynthese Neuraler Strukturen Universität Hamburg Martinistr. 52 20246 Hamburg GERMANY
Country:	Germany
Phone:	49-40-42803-6246
Fax:	49-40-42803-6248
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Joseph, T.P., Jagadeesan, N., Sai, L.Y., Lin, S.L., Sahu, S., Schachner, M. (2020) Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish. Frontiers in neuroscience. 14:458

Pan, H., Xue, W., Zhao, W., Schachner, M. (2019) Expression and function of chondroitin 4-sulfate and chondroitin 6-sulfate in human glioma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(2):2853-2868

Fan, Y., Xue, W., Schachner, M., Zhao, W. (2018) Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells Via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor. Cancers. 11(1)

Sahu, S., Li, R., Loers, G., Schachner, M. (2018) Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafish after spinal cord injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(2):2252-2262

Li, R., Sahu, S., Schachner, M. (2018) Phenelzine, a cell adhesion molecule L1 mimetic small organic compound, promotes functional recovery and axonal regrowth in spinal cord-injured zebrafish. Pharmacology, biochemistry, and behavior. 171:30-38

Theis, T., Yoo, M., Park, C.S., Chen, J., Kügler, S., Gibbs, K.M., Schachner, M. (2017) Lentiviral Delivery of miR-133b Improves Functional Recovery After Spinal Cord Injury in Mice. Molecular neurobiology. 54(6):4659-4671

Ma, L., Shen, H.F., Shen, Y.Q., Schachner, M. (2017) The Adhesion Molecule-Characteristic HNK-1 Carbohydrate Contributes to Functional Recovery After Spinal Cord Injury in Adult Zebrafish. Molecular neurobiology. 54(5):3253-3263

Sahu, S., Zhang, Z., Li, R., Hu, J., Shen, H., Loers, G., Shen, Y., Schachner, M. (2017) A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish. Molecular neurobiology. 55(1):859-878

Liu, C.J., Xie, L., Cui, C., Chu, M., De Zhao, H., Yao, L., Li, Y.H., Schachner, M., Shen, Y.Q. (2016) Beneficial roles of melanoma cell adhesion molecule in spinal cord transection recovery in adult zebrafish. Journal of neurochemistry. 139(2):187-196

Chen, T., Yu, Y., Hu, C., Schachner, M. (2016) L1.2, the zebrafish paralog of L1.1 and ortholog of the mammalian cell adhesion molecule L1 contributes to spinal cord regeneration in adult zebrafish. Restorative neurology and neuroscience. 34(2):325-35

Jeong, Y.M., Jin, T.E., Choi, J.H., Lee, M.S., Kim, H.T., Hwang, K.S., Park, D.S., Oh, H.W., Choi, J.K., Korzh, V., Schachner, M., You, K.H., Kim, C.H. (2014) Induction of clusterin Expression by Neuronal Cell Death in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 41:583-9

Liu, D., Yu, Y., Schachner, M. (2014) Ptena, but not Ptenb, reduces regeneration after spinal cord injury in adult zebrafish. Experimental neurology. 261:196-205

Ma, L., Shen, Y.Q., Khatri, H.P., Schachner, M. (2014) The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish. PLoS One. 9:e95098

Fang, P., Pan, H.C., Lin, S.L., Zhang, W.Q., Rauvala, H., Schachner, M., and Shen, Y.Q. (2014) HMGB1 Contributes to Regeneration After Spinal Cord Injury in Adult Zebrafish. Molecular neurobiology. 49(1):472-83

Yu, Y., and Schachner, M. (2013) Syntenin-a promotes spinal cord regeneration following injury in adult zebrafish. The European journal of neuroscience. 38(2):2280-9

Pan, H.C., Lin, J.F., Ma, L.P., Shen, Y.Q., and Schachner, M. (2013) Major vault protein promotes locomotor recovery and regeneration after spinal cord injury in adult zebrafish. The European journal of neuroscience. 37(2):203-211

Fang, P., Lin, J.F., Pan, H.C., Shen, Y.Q., and Schachner, M. (2012) A surgery protocol for adult zebrafish spinal cord injury. Journal of genetics and genomics = Yi chuan xue bao. 39(9):481-487

Ma, L., Yu, Y.M., Guo, Y., Hart, R.P., and Schachner, M. (2012) Cysteine- and glycine-rich protein 1a is involved in spinal cord regeneration in adult zebrafish. The European journal of neuroscience. 35(3):353-365

Lin, J.F., Pan, H.C., Ma, L.P., Shen, Y.Q., and Schachner, M. (2012) The Cell Neural Adhesion Molecule Contactin-2 (TAG-1) Is Beneficial for Functional Recovery after Spinal Cord Injury in Adult Zebrafish. PLoS One. 7(12):e52376

Yu, Y.M., Cristofanilli, M., Valiveti, A., Ma, L., Yoo, M., Morellini, F., and Schachner, M. (2011) The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish. Neuroscience. 183:238-50

Yu, Y.M., Gibbs, K.M., Davila, J., Campbell, N., Sung, S., Todorova, T.I., Otsuka, S., Sabaawy, H.E., Hart, R.P., and Schachner, M. (2011) MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish. The European journal of neuroscience. 33(9):1587-97

Guo, Y., Ma, L., Cristofanilli, M., Hart, R.P., Hao, A., and Schachner, M. (2011) Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish. Neuroscience. 172:329-341

Schweitzer, J., Gimnopoulos, D., Lieberoth, B.C., Pogoda, H.M., Feldner, J., Ebert, A., Schachner, M., Becker, T., and Becker, C.G. (2007) Contactin1a expression is associated with oligodendrocyte differentiation and axonal regeneration in the central nervous system of zebrafish. Molecular and cellular neurosciences. 35(2):194-207

Schweitzer, J., Becker, T., Schachner, M., Nave, K.A., and Werner, H. (2006) Evolution of myelin proteolipid proteins: Gene duplication in teleosts and expression pattern divergence. Molecular and cellular neurosciences. 31(1):161-177

Feldner, J., Becker, T., Goishi, K., Schweitzer, J., Lee, P., Schachner, M., Klagsbrun, M., and Becker, C.G. (2005) Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(3):535-549

Schweitzer, J., Becker, T., Lefebvre, J., Granato, M., Schachner, M., and Becker, C.G. (2005) Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(3):550-566

Becker, T., Lieberoth, B.C., Becker, C.G., and Schachner, M. (2005) Differences in the regenerative response of neuronal cell populations and indications for plasticity in intraspinal neurons after spinal cord transection in adult zebrafish. Molecular and cellular neurosciences. 30(2):265-278

Schweitzer, J., Becker, C.G., Schachner, M., and Becker, T. (2005) Expression of collapsin response mediator proteins in the nervous system of embryonic zebrafish. Gene expression patterns : GEP. 5(6):809-816

Becker, C.G., Lieberoth, B.C., Morellini, F., Feldner, J., Becker, T., and Schachner, M. (2004) L1.1 is involved in spinal cord regeneration in adult zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(36):7837-7842

Becker, C.G., Schweitzer, J., Feldner, J., Schachner, M., and Becker, T. (2004) Tenascin-R as a repellent guidance molecule for newly growing and regenerating optic axons in adult zebrafish. Molecular and cellular neurosciences. 26(3):376-389

Becker, C.G., Schweitzer, J., Feldner, J., Becker, T., and Schachner, M. (2003) Tenascin-R as a repellent guidance molecule for developing optic axons in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(15):6232-6237

Schweitzer, J., Becker, T., Becker, C.G., and Schachner, M. (2003) Expression of protein zero is increased in lesioned axon pathways in the central nervous system of adult zebrafish. Glia. 41(3):301-317

Gimnopoulos, D., Becker, C.G., Ostendorff, H.P., Bach, I., Schachner, M., and Becker, T. (2002) Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Mechanisms of Development. 119:S135-S141

Becker, T., Becker, C.G., Schachner, M., and Bernhardt, R.R. (2001) Antibody to the HNK-1 glycoepitope affects fasciculation and axonal pathfinding in the developing posterior lateral line nerve of embryonic zebrafish. Mechanisms of Development. 109(1):37-49

Pradel, G., Schmidt, R., and Schachner, M. (2000) Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish. Journal of neurobiology. 43(4):389-403

Bernhardt, R.R. and Schachner, M. (2000) Chondroitin sulfates affect the formation of the segmental motor nerves in zebrafish embryos. Developmental Biology. 221(1):206-219

Roos, M., Schachner, M., and Bernhardt, R.R. (1999) Zebrafish semaphorin Z1b inhibits growing motor axons in vivo. Mechanisms of Development. 87(1-2):103-117

Pradel, G., Schachner, M., and Schmidt, R. (1999) Inhibition of memory consolidation by antibodies against cell adhesion molecules after active avoidance conditioning in zebrafish. Journal of neurobiology. 39(2):197-206

Bernhardt, R.R., Goerlinger, S., Roos, M., and Schachner, M. (1998) Anterior-posterior subdivision of the somite in embryonic zebrafish: implications for motor axon guidance. Developmental Dynamics : an official publication of the American Association of Anatomists. 213:334-347

Becker, T., R.R. Bernhardt, E. Reinhard, M.F. Wullimann, E. Tongiorgi, and M. Schachner (1998) Readiness of zebrafish brain neurons to regenerate a spinal axon correlates with differential expression of specific cell recognition molecules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18:5789-5803

Weber, P., Montag, D., Schachner, M., and Bernhardt, R.R. (1998) Zebrafish tenascin-W, a new member of the tenascin family. Journal of neurobiology. 35:1-16

Becker, T., Wullimann, M.F., Becker, C.G., Bernhardt, R.R., and Schachner, M. (1997) Axonal regrowth after spinal cord transection in adult zebrafish. The Journal of comparative neurology. 377(4):577-595

Bernhardt, R.R., Tongiorgi, E., Anzini, P., and Schachner, M. (1996) Increased expression of specific recognition molecules by retinal ganglion cells and by optic pathway glia accompanies the successful regeneration of retinal axons in adult zebrafish. The Journal of comparative neurology. 376(2):253-264

Appel, C., Gloor, S., Schmalzing, G., Schachner, M., and Bernhardt, R.R. (1996) Expression of a Na,K-ATPase Beta3 subunit during development of the zebrafish central nervous system. Journal of neuroscience research. 46(5):551-564

Holm, J., Hillenbrand, R., Steuber, V., Bartsch, U., Moos, M., Lubbert, H., Montag, D., and Schachner, M. (1996) Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. The European journal of neuroscience. 8(8):1613-1629

Tongiorgi, E., Bernhardt, R.R., and Schachner, M. (1995) Zebrafish neurons express two L1-related molecules during early axonogenesis. Journal of neuroscience research. 42:547-561

Tongiorgi, E., Bernhardt, R.R., Zinn, K., and Schachner, M. (1995) Tenascin-C mRNA is expressed in cranial neural crest cells, in some placodal derivatives, and in discrete domains of the embryonic zebrafish brain. Journal of neurobiology. 28:391-407