ZFIN Company: Summit plc

ZFIN ID: ZDB-COMPANY-050920-1

ZFIN ID: ZDB-COMPANY-050920-1

Summit plc

Contact Person:	Hill, Adrian
Email:
URL:	http://www.summitplc.com
Address:	91 Milton Park Abingdon Oxfordshire OX14 4RY UK
Country:	United Kingdom
Phone:	44 (0)1235 443967
Fax:	44 (0)1235 443999
Line Designation:	None assigned

PRODUCTS AND SERVICES

Summit plc (formerly VASTox plc) is a leading UK biotechnology company that discovers and develops proprietary new drugs. The Company’s internal drug development programmes are underpinned by its two world-leading technology platforms in carbohydrate chemistry and zebrafish drug screening (chemical genomics), which it also provides on a collaborative or fee-for-service basis to the pharmaceutical industry.

Summit plc has a broad range of drug discovery programmes in the clinical, pre-clinical and discovery stages of development, which target serious diseases with a high unmet medical need. These therapeutic areas include neuro-disorders (neurodegenerative and neuromuscular), infectious diseases, cancer, ophthalmic diseases and regenerative medicine.

The company was founded in February 2003 and listed on the AIM market of the London Stock Exchange in October 2004 – symbol: [SUMM].

COMPANY REPRESENTATIVES

Hill, Adrian Executive

ZEBRAFISH PUBLICATIONS OF COMPANY REPRESENTATIVES

Hill, A., Mesens, N., Steemans, M., Xu, J.J., and Aleo, M.D. (2012) Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development. Drug Metabolism Reviews. 44(1):127-140

Van den Bulck, K., Hill, A., Mesens, N., Diekman, H., De Schaepdrijver, L., and Lammens, L. (2011) Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?. Reproductive toxicology (Elmsford, N.Y.). 32(2):213-9

Hill, A.J., Heiden, T.C., Heideman, W., and Peterson, R.E. (2009) Potential roles of arnt2 in zebrafish larval development. Zebrafish. 6(1):79-91

Berghmans, S., Barros, T., Golder, Z., Gardner, I., Butler, P., Hill, A., Fleming, A., Alderton, W., and Roach, A. (2008) Zebrafish: The future of in vivo safety pharmacology screening. Journal of Pharmacological and Toxicological Methods. 58(2):177-178

Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., and Hiraga, T. (2006) Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquatic toxicology (Amsterdam, Netherlands). 78(2):103-113

Hill, A.J., Teraoka, H., Heideman, W., and Peterson, R.E. (2005) Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 86(1):6-19

Hill, A., Howard, V., and Cossins, A. (2004) Characterization of TCDD-induced craniofacial malformations and retardation of zebrafish growth. Journal of Fish Biology. 64(4):911

Hill, A.J., Bello, S.M., Prasch, A.L., Peterson, R.E., and Heideman, W. (2004) Water permeability and TCDD-induced edema in zebrafish early-life stages. Toxicological sciences : an official journal of the Society of Toxicology. 78(1):78-87

Hill, A., Howard, C.V., Strähle, U., and Cossins, A. (2003) Neuro-developmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrations. Toxicological sciences : an official journal of the Society of Toxicology. 76(2):392-399

Hill, A.J., Howard, C.V., and Cossins, A.R. (2002) Efficient embedding technique for preparing small specimens for stereological volume estimation: zebrafish larvae. Journal of microscopy. 206(3):179-181

Hill, A., Howard, V., Müller, F. and Cossins, A. (2001) Effect of 2,3,7,8-tetrachlorodibenzo-p dioxin on early development and the neurogenesis pathway in the zebrafish (Danio rerio). Organohalogen Compounds. 53:207-210