PCSK9-LDLR complex

Term ID

GO:1990666

Synonyms

• PCSK9.LDLR complex
• PCSK9/LDL-R complex
• PCSK9:EGF-A complex
• PCSK9:low-density lipoprotein receptor complex

Definition

A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO