STING complex

Term ID

GO:1990231

Synonyms

• stimulator of interferon genes complex

Definition

A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. (3)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO