negative regulation of protein import into nucleus during spindle assembly checkpoint

Term ID

GO:1901925

Synonyms

• Kap121p transport inhibitory pathway
• KTIP
• negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint

Definition

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). 23177738

References

Ontology

GO: Biological Process    QuickGO    AmiGO