nuclear receptor corepressor activity

Term ID

GO:0140536

Synonyms

• nuclear corepressor activity

Definition

A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. (3)

References

Ontology

GO: Molecular Function    QuickGO    AmiGO