ubiquitin activating enzyme complex

Term ID

GO:0120123

Synonyms

• E1 complex

Definition

A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. 9545234

References

Ontology

GO: Cellular Component    QuickGO    AmiGO