intrinsic apoptotic signaling pathway

Term ID

GO:0097193

Synonyms

• induction of apoptosis by intracellular signals
• intrinsic apoptosis
• intrinsic apoptotic pathway
• intrinsic apoptotic signalling pathway
• mitochondrial-mediated apoptotic pathway

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). (3)

References

Ontology

GO: Biological Process    QuickGO    AmiGO