RISC complex assembly

Term ID

GO:0070922

Synonyms

• gene silencing by RNA, small RNA loading onto RISC
• miRISC assembly
• miRNA loading onto RISC
• RISC assembly
• siRNA loading onto RISC involved in gene silencing by small RNA
• siRNA loading onto RISC involved in RNA interference
• small RNA loading onto RISC

Definition

The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA. (5)

References

Ontology

GO: Biological Process    QuickGO    AmiGO