Notch receptor processing, ligand-dependent

Term ID

GO:0035333

Synonyms

• Notch S2 cleavage
• Notch S3 cleavage

Definition

The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). 12651094

References

Ontology

GO: Biological Process    QuickGO    AmiGO