IkappaB kinase complex

Term ID

GO:0008385

Synonyms

• heterotrimeric IKK complex
• IKK complex
• trimeric IKK complex

Definition

A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO