Search Ontology:

GO: Molecular Function

cholesterol 7-alpha-monooxygenase activity

Term ID

GO:0008123

Synonyms

cholesterol 7-alpha-hydroxylase activity
cholesterol 7alpha-hydroxylase activity
cholesterol 7alpha-monooxygenase activity
cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
cytochrome P450 CYP7A1

Definition

Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. 1.14.14.23

References

EC:1.14.14.23
MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
RHEA:21812
Reactome:R-HSA-192051

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity Show first 5 Terms

Phenotype

Phenotype caused by Genes

Citations