promyelocyte

Term ID

CL:0000836

Synonyms

Definition

A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative. (2)

References

CALOHA:TS-0825
FMA:83530

Ontology

Cell Ontology

Relationships

develops from: myeloblast

myeloblast Show first 5 Terms
develops into: myelocyte

myelocyte Show first 5 Terms
is a type of: granulocytopoietic cell myeloid cell myeloid lineage restricted progenitor cell nucleate cell

granulocytopoietic cell myeloid cell myeloid lineage restricted progenitor cell nucleate cell Show first 5 Terms
has subtype: basophilic promyelocyte early promyelocyte eosinophilic promyelocyte late promyelocyte neutrophilic promyelocyte

basophilic promyelocyte early promyelocyte eosinophilic promyelocyte late promyelocyte neutrophilic promyelocyte Show first 5 Terms
has_part: azurophil granule anatomy-visibility anatomy-visibility nucleolus

azurophil granule anatomy-visibility anatomy-visibility nucleolus Show first 5 Terms
has_plasma_membrane_part: alpha-(1,3)-fucosyltransferase FUT4 CD33 molecule

alpha-(1,3)-fucosyltransferase FUT4 CD33 molecule Show first 5 Terms
lacks_plasma_membrane_part: integrin alpha-M low affinity immunoglobulin gamma Fc region receptor III signal transducer CD24

integrin alpha-M low affinity immunoglobulin gamma Fc region receptor III signal transducer CD24 Show first 5 Terms