hepatic stellate cell

Term ID

CL:0000632

Synonyms

• fat-storing cell
• hepatic perisinusoidal cell
• Ito cell
• lipocyte
• perisinusoidal cell
• vitamin A-storing cells

Definition

A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. (6)

References

• BTO:0002741
• CALOHA:TS-0452
• FMA:67763

Ontology

Cell Ontology