trandolapril

Term ID

CHEBI:9649

Synonyms

• (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
• (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
• Gopten
• Mavik
• Odrik
• RU 44570
• RU-44570
• RU44570
• trandolapril
• trandolaprilum

Definition

A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.

References

• CAS:87679-37-6
• Chemspider:4588590
• DrugBank:DB00519
• Drug_Central:2712
• HMDB:HMDB0014660
• KEGG:D00383
• PMID:1648489
• PMID:19337528
• PMID:22247843
• PMID:23784370
• PMID:24835355
• PMID:25802524
• PMID:25864194
• PMID:26915813
• PMID:27215243
• PMID:29319234
• PMID:32964020
• PMID:33660934
• PMID:3383998
• PMID:34172790
• PMID:8515499
• PMID:8515500
• PMID:8515501
• PMID:8515502
• PMID:8515504
• PMID:9770740
• Patent:KR20080046630
• Patent:WO2006014916
• Reaxys:8655766
• Wikipedia:Trandolapril

Ontology

ChEBI  ( EBI )