tetrabenazine

Term ID

CHEBI:9467

Synonyms

1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one
1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-one
2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine
Nitoman
rac-(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
Ro 1-9569
TBZ
tetrabenazina
tetrabenazine
tetrabenazinum
Xenazine

Definition

A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia.

References

CAS:58-46-8
DrugBank:DB04844
KEGG:C11168
KEGG:D08575
PMID:10686169
PMID:19929707
PMID:20442355
PMID:20869622
PMID:21487088
PMID:9040721
Patent:US2830993
Reaxys:9356999
Wikipedia:Tetrabenazine

Ontology

ChEBI ( EBI )

Relationships

is a type of: racemate

racemate Show first 5 Terms
has_part: (3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one

(3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Show first 5 Terms
has_role: adrenergic uptake inhibitor antipsychotic agent

adrenergic uptake inhibitor antipsychotic agent Show first 5 Terms

Phenotype

Phenotype resulting from tetrabenazine

Phenotype where environments contain tetrabenazine

Phenotype modified by environments containing tetrabenazine

Human Disease / Model Data

Citations