ML228

Term ID

CHEBI:92777

Synonyms

• 6-phenyl-N-[(4-phenylphenyl)methyl]-3-(2-pyridinyl)-1,2,4-triazin-5-amine
• LSM-2978
• ML-228
• ML228 probe
• N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
• N-([biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine

Definition

A member of the class of 1,2,4-triazines in which the triazine ring is substituted at positions 3, 5, and 6 by pyridin-2-yl, ([biphenyl]-4-ylmethyl)amin, and methyl groups, respectively. It is an activator of the hypoxia inducible factor (HIF) pathway.

References

• LINCS:LSM-2978
• PMID:22172704
• PMID:26987747
• PMID:27383646
• PMID:27549025
• Reaxys:22196087

Ontology

ChEBI  ( EBI )