PF-00477736

Term ID

CHEBI:91385

Synonyms

• (2R)-2-amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-4H-[1,2]diazepino[4,5,6-cd]indol-8-yl]acetamide
• PF 477736
• PF-477736

Definition

A diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1).

References

• cas:952021-60-2
• lincs.smallmolecule:LSM-1112
• pubmed:18694366
• pubmed:19584159
• pubmed:23820871
• pubmed:24838526
• pubmed:25104095
• pubmed:25428911
• pubmed:25465126
• pubmed:26439697
• pubmed:26542114

Ontology

ChEBI  ( EBI )