tivozanib

Term ID

CHEBI:91327

Synonyms

1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea
1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea
AV 951
AV-951
AV951
Kil 8951
KIL-8951
KRN 951
KRN-951
KRN951
N-[2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea
tivozanib
tivozanibum

Definition

A member of the class of quinolines that is 6,7-dimethoxyquinoline substituted by a 3-chloro-4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}phenoxy group at position 4. It is a potent and selective inhibitor of VEGF receptor tyrosine kinases and was previously in clinical development for the treatment of metastatic renal cell carcinoma.

References

cas:475108-18-0
drugbank:DB11800
hmdb:HMDB0304847
kegg.drug:D09683
lincs.smallmolecule:LSM-1005
patent:US7166722
pdb-ccd:AV9
pubmed:20799147
pubmed:21976547
pubmed:22493422
pubmed:22988103
pubmed:23141221
pubmed:23252559
pubmed:23580238
pubmed:23726267
pubmed:24295377
pubmed:29547835
pubmed:32692256
pubmed:35698870
pubmed:35718972
pubmed:35848061
pubmed:35916102
pubmed:36096984
pubmed:36399037
pubmed:36576430
pubmed:36912078
pubmed:37012938
pubmed:37023219
pubmed:37146497
pubmed:37259438
pubmed:37285073
pubmed:37315114
pubmed:37745049
pubmed:37991373
pubmed:38262444
pubmed:38478923
pubmed:38682168
wikipedia.en:Tivozanib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from tivozanib

Phenotype where environments contain tivozanib

Phenotype modified by environments containing tivozanib

Phenotype affecting tivozanib

Human Disease Model