osimertinib

Term ID

CHEBI:90943

Synonyms

AZD 9291
AZD-9291
AZD9291
mereletinib
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
osimertinib
osimertinibum

Definition

A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.

References

cas:1421373-65-0
drugbank:DB09330
drugcentral:5062
hmdb:HMDB0248778
lincs.smallmolecule:LSM-6344
patent:WO2019138346
pubmed:26450446
pubmed:26515464
pubmed:26620497
pubmed:26720284
pubmed:26720671
pubmed:26729184
pubmed:29151359
pubmed:29782558
pubmed:29852038
pubmed:29999920
pubmed:30034220
pubmed:30126856
pubmed:30151614
pubmed:30153097
pubmed:30189719
pubmed:30194172
pubmed:30224350
pubmed:30358214
pubmed:30916819
pubmed:31446643
pubmed:32569688
pubmed:33163272
pubmed:33896242
pubmed:34303194
pubmed:34734065
pubmed:35015529
pubmed:35793806
pubmed:36031292
pubmed:36093451
pubmed:36104273
pubmed:36201715
pubmed:36210715
pubmed:36237272
pubmed:36258694
pubmed:36328480
pubmed:36354696
pubmed:36373445
pubmed:36420659
pubmed:36480925
pubmed:36527745
pubmed:36543437
pubmed:36544540
pubmed:36575215
pubmed:36578073
pubmed:36597021
pubmed:36638566
pubmed:37516900
pubmed:38115126
reaxys:23334373
wikipedia.en:Osimertinib

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from osimertinib

Phenotype where environments contain osimertinib

Phenotype modified by environments containing osimertinib

Phenotype affecting osimertinib

Human Disease Model