tenofovir alafenamide

Term ID

CHEBI:90926

Synonyms

GS 7340
GS-7340
propan-2-yl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate
TAF
tenofovir alafenamide

Definition

An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection.

References

CAS:379270-37-8
DrugBank:DB09299
Drug_Central:4944
KEGG:D10428
Reaxys:8948831
Wikipedia:Tenofovir_alafenamide

Ontology

ChEBI ( EBI )

Relationships

is a type of: 6-aminopurines ether isopropyl ester L-alanine derivative phosphoramidate ester

6-aminopurines ether isopropyl ester L-alanine derivative phosphoramidate ester Show first 5 Terms
has_functional_parent: adenine

adenine Show first 5 Terms
has_role: antiviral drug HIV-1 reverse transcriptase inhibitor prodrug

antiviral drug HIV-1 reverse transcriptase inhibitor prodrug Show first 5 Terms
inverse is_conjugate_acid_of: tenofovir alafenamide(1+)

tenofovir alafenamide(1+) Show first 5 Terms
is_conjugate_base_of: tenofovir alafenamide(1+)

tenofovir alafenamide(1+) Show first 5 Terms

Phenotype

Phenotype resulting from tenofovir alafenamide

Phenotype where environments contain tenofovir alafenamide

Phenotype modified by environments containing tenofovir alafenamide

Human Disease / Model Data

Citations