rolapitant hydrochloride (anhydrous)

Term ID

CHEBI:90912

Synonyms

(5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-oxo-8-phenyl-1,7-diazaspiro[4.5]decan-7-ium chloride
(5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride
rolapitant hydrochloride
Rolapitant hydrochloride anhydrous
rolapitant monohydrochloride
rolapitant.HCl
SCH 619734
SCH619734

Definition

A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of the hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

References

CAS:858102-79-1
PMID:26467681
PMID:26535019
Reaxys:15570171

Ontology

ChEBI ( EBI )

Relationships

is a type of: hydrochloride

hydrochloride Show first 5 Terms
has_part: rolapitant(1+)

rolapitant(1+) Show first 5 Terms
has_role: antiemetic neurokinin-1 receptor antagonist

antiemetic neurokinin-1 receptor antagonist Show first 5 Terms
inverse has_part: rolapitant hydrochloride hydrate

rolapitant hydrochloride hydrate Show first 5 Terms

Phenotype

Phenotype resulting from rolapitant hydrochloride (anhydrous)

Phenotype where environments contain rolapitant hydrochloride (anhydrous)

Phenotype modified by environments containing rolapitant hydrochloride (anhydrous)

Human Disease / Model Data

Citations