Search Ontology:
ChEBI
cobimetinib
- Term ID
- CHEBI:90851
- Synonyms
-
- [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
- cobimetinib
- GDC 0973
- GDC-0973
- GDC0973
- RG 7420
- RG7420
- Xl 518
- Xl-518
- XL518
- Definition
- A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.
- References
-
- CAS:934660-93-2
- DrugBank:DB05239
- Drug_Central:5046
- KEGG:D10405
- PDBeChem:EUI
- PMID:24589925
- PMID:25037139
- PMID:25142409
- PMID:25243894
- PMID:25265494
- PMID:25444546
- PMID:25813936
- PMID:26365290
- PMID:26384788
- PMID:26451002
- PMID:26452567
- Reaxys:12883594
- Wikipedia:Cobimetinib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
- inverse is_conjugate_acid_of
-
- is_conjugate_base_of
-
Show All 7 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from cobimetinib
Phenotype where environments contain cobimetinib
Phenotype modified by environments containing cobimetinib
Human Disease / Model Data
Citations