FR171456

Term ID

CHEBI:88298

Synonyms

(3beta,4alpha,5alpha,8alpha,9beta,11alpha)-3,8,11-trihydroxy-4-methyl-1,6-dioxo-9,19-cycloergost-24(28)-ene-4-carboxylic acid
3beta,8alpha,11alpha-trihydroxy-4-methyl-1,6-dioxo-9beta,19-cyclo-5alpha-ergost-24(28)-ene-4alpha-carboxylic acid

Definition

A steroid acid that is 9beta,19-cyclo-5alpha-ergost-24(28)-ene-4alpha-carboxylic acid which is substituted by hydroxy groups at the 3beta, 8alpha, and 11alpha positions, by a methyl group at the 4beta position, and by oxo groups at positions 1 and 6. It is a cholesterol and ergosterol synthesis inhibitor isolated from the fungus Sporormiella minima that specifically targets the enzyme, sterol-4-alpha-carboxylate-3-dehydrogenase, encoded by ERG26 in budding yeast, and NSDHL in humans.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 3beta-hydroxy steroid 6-oxo steroid 8-hydroxy steroid 11alpha-hydroxy steroid cyclopropanes ... Show All 6 Terms

3beta-hydroxy steroid 6-oxo steroid 8-hydroxy steroid 11alpha-hydroxy steroid cyclopropanes steroid acid Show first 5 Terms
has_role: antifungal agent EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor ergosterol biosynthesis inhibitor fungal metabolite

antifungal agent EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor ergosterol biosynthesis inhibitor fungal metabolite Show first 5 Terms

Phenotype

Phenotype resulting from FR171456

Phenotype where environments contain FR171456

Phenotype modified by environments containing FR171456

Human Disease / Model Data

Citations