naloxone

Term ID

CHEBI:7459

Synonyms

(-)-naloxone
1-N-Allyl-14-hydroxynordihydromorphinone
17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one
3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
naloxona
naloxone
naloxonum

Definition

A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.

References

Beilstein:1089071
CAS:465-65-6
DrugBank:DB01183
Drug_Central:1878
HMDB:HMDB0015314
KEGG:C07252
KEGG:D08249
LINCS:LSM-3504
PMID:17023477
PMID:24868924
PMID:25468814
PMID:26469689
PMID:26604818
PMID:26634308
Patent:GB939287
Patent:US3254088
Reaxys:1089071
Wikipedia:Naloxone

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: morphinane alkaloid organic heteropentacyclic compound tertiary alcohol

morphinane alkaloid organic heteropentacyclic compound tertiary alcohol Show first 5 Terms
has_parent_hydride: morphinan

morphinan Show first 5 Terms
has_role: antidote to opioid poisoning central nervous system depressant mu-opioid receptor antagonist

antidote to opioid poisoning central nervous system depressant mu-opioid receptor antagonist Show first 5 Terms
inverse has_functional_parent: naloxegol

naloxegol Show first 5 Terms
inverse is_conjugate_acid_of: naloxone(1+)

naloxone(1+) Show first 5 Terms
is_conjugate_base_of: naloxone(1+)

naloxone(1+) Show first 5 Terms

Phenotype

Phenotype resulting from naloxone

Phenotype where environments contain naloxone

Phenotype modified by environments containing naloxone

Human Disease / Model Data

Citations