dasatinib monohydrate

Term ID

CHEBI:70839

Synonyms

• BMS 354825-03
• BMS 35482503
• dasatinib
• dasatinib hydrate
• dasatinib.H2O
• N-(2-chloro-6-methylphenyl)-2-((6-(4-(2- hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate
• N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide--water (1/1)
• Sprycel

Definition

A hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).

References

• CAS:863127-77-9
• KEGG:D06414
• PMID:18223208
• PMID:19749489
• PMID:21226671
• PMID:22233429
• Patent:WO2005077945
• Patent:WO2010067374
• Patent:WO2010139979
• Patent:WO2010139980
• Patent:WO2011095059
• Reaxys:14444783

Ontology

ChEBI  ( EBI )