icatibant

Term ID

CHEBI:68556

Synonyms

• (2S)-2-({[(2S,3aS,7aS)-1-({(3R)-2-[(2S)-2-{[(2S)-2-[2-({[(2S,4R)-1-({(2S)-1-[(2S)-2-{[(2R)-2-amino-5-carbamimidamidopentanoyl]amino}-5-carbamimidamidopentanoyl]pyrrolidin-2-yl}carbonyl)-4-hydroxypyrrolidin-2-yl]carbonyl}amino)acetamido]-3-(thiophen-2-yl)p
• D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-L-arginine
• H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
• icatibant
• icatibanto
• icatibantum

Definition

A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients.

References

• cas:130308-48-4
• drugbank:DB06196
• pubmed:21959973
• pubmed:22142018
• pubmed:22386830
• pubmed:22434085
• pubmed:22435954
• pubmed:22507340
• pubmed:22519593
• pubmed:22522852
• pubmed:22552531
• pubmed:22577166
• pubmed:22577920
• pubmed:22584193
• pubmed:22686628
• pubmed:22691903
• pubmed:22797560
• pubmed:22830287
• pubmed:22904641
• pubmed:22936825
• pubmed:22958093
• pubmed:22970904
• reaxys:8185933
• wikipedia.en:Icatibant

Ontology

ChEBI  ( EBI )

Resources

CTD