glionitrin A

Term ID

CHEBI:65967

Synonyms

(3S,10aS)-3-(hydroxymethyl)-2-methyl-7-nitro-2,3-dihydro-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione

Definition

A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring. It is an antibiotic isolated from the microbial strains Sphingomonas and Aspergillus fumigatus, and exhibits cytotoxic activity against four human cancer cell lines: HCT-116, A549, AGS, and DU145.

References

CAS:1116153-15-1
PMID:19159274
PMID:22947415
Reaxys:19154490

Ontology

ChEBI ( EBI )

Relationships

is a type of: C-nitro compound organic disulfide organic heterotetracyclic compound pyrazinoindole

C-nitro compound organic disulfide organic heterotetracyclic compound pyrazinoindole Show first 5 Terms
has_role: antimicrobial agent antineoplastic agent Aspergillus metabolite

antimicrobial agent antineoplastic agent Aspergillus metabolite Show first 5 Terms

Phenotype

Phenotype resulting from glionitrin A

Phenotype where environments contain glionitrin A

Phenotype modified by environments containing glionitrin A

Human Disease / Model Data

Citations