Search Ontology:
ChEBI

bevirimat

Term ID
CHEBI:65484
Synonyms
  • (3beta)-3-[(3-carboxy-3-methylbutanoyl)oxy]lup-20(29)-en-28-oic acid
  • 3-O-(3',3'-dimethylsuccinyl) betulinic acid
  • bevirimat
  • bevirimatum
  • BVM
  • PA-457
Definition
A pentacyclic triterpenoid obtained by the formal condensation of 2,2-dimethylsuccinic acid with the 3-hydroxy group of betulinic acid. It is isolated from the Chinese herb Syzygium claviflorum. The first in the class of HIV-1 maturation inhibitors to be studied in humans, bevirimat was identified as a potent HIV drug candidate and several clinical trials were conducted, but development into a new drug was plagued by numerous resistance-related problems.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from bevirimat
Phenotype where environments contain bevirimat
Phenotype modified by environments containing bevirimat
Human Disease / Model Data
Citations
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