australifungin

Term ID

CHEBI:65459

Synonyms

(4S,4aR,5S,7R,8R,8aS)-2,5,8-trihydroxy-4-[(2Z)-3-hydroxyprop-2-enoyl]-4,7-dimethyl-3-[(2R)-octan-2-yl]-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one

Definition

A carbobicyclic compound that is 4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one substituted by hydroxy groups at positions 2, 5 and 8, a (2Z)-3-hydroxyprop-2-enoyl group at position 4, methyl groups at positions 4 and 7 and a 2R-octan-2-yl group at position 3 (the 4S,4aR,5S,7R,8R,8aS stereoisomer). It is isolated from the fermentation extracts of Sporormiella australis and exhibits antifungal activity by interfering with the fungal lipid metabolism.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: carbobicyclic compound enol enone secondary alcohol

carbobicyclic compound enol enone secondary alcohol Show first 5 Terms
has_role: antifungal agent EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor HIV-1 integrase inhibitor metabolite

antifungal agent EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor HIV-1 integrase inhibitor metabolite Show first 5 Terms

Phenotype

Phenotype resulting from australifungin

Phenotype where environments contain australifungin

Phenotype modified by environments containing australifungin

Human Disease / Model Data

Citations