sulindac sulfone

Term ID

CHEBI:64212

Synonyms

5-Fluoro-2-methyl-1-((Z)-p-(methylsulfonyl)benzylidene)indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acid
exisulind
{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid

Definition

A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.

References

cas:59973-80-7
drugcentral:3219
patent:EP1336602
patent:US5696159
patent:US5776962
pubmed:17016604
pubmed:20332437
pubmed:20374023
pubmed:21515355
pubmed:21735687
pubmed:22364235
reaxys:7887099
wikipedia.en:Exisulind

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from sulindac sulfone

Phenotype where environments contain sulindac sulfone

Phenotype modified by environments containing sulindac sulfone

Phenotype affecting sulindac sulfone

Human Disease Model