vanoxerine

Term ID

CHEBI:64089

Synonyms

1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine
GBR 12909
GBR12909
vanoxerina
vanoxerine
vanoxerinum

Definition

An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: ether N-alkylpiperazine organofluorine compound tertiary amino compound

ether N-alkylpiperazine organofluorine compound tertiary amino compound Show first 5 Terms
has_role: dopamine uptake inhibitor

dopamine uptake inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: vanoxerine(2+)

vanoxerine(2+) Show first 5 Terms
is_conjugate_base_of: vanoxerine(2+)

vanoxerine(2+) Show first 5 Terms

Phenotype

Phenotype resulting from vanoxerine

Phenotype where environments contain vanoxerine

Phenotype modified by environments containing vanoxerine

Human Disease / Model Data

Citations