sotalol

Term ID

CHEBI:63622

Synonyms

4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide
beta-cardone
N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
sotalol
sotalolum

Definition

A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.

References

CAS:3930-20-9
DrugBank:DB00489
Drug_Central:2464
HMDB:HMDB0014632
KEGG:C07309
KEGG:D08525
LINCS:LSM-1465
PMID:20562595
PMID:21553267
PMID:21854895
Reaxys:2380820
Wikipedia:Sotalol

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: ethanolamines secondary alcohol secondary amino compound sulfonamide

ethanolamines secondary alcohol secondary amino compound sulfonamide Show first 5 Terms
has_role: anti-arrhythmia drug beta-adrenergic antagonist environmental contaminant xenobiotic

anti-arrhythmia drug beta-adrenergic antagonist environmental contaminant xenobiotic Show first 5 Terms
inverse is_conjugate_acid_of: sotalol(1+)

sotalol(1+) Show first 5 Terms
is_conjugate_base_of: sotalol(1+)

sotalol(1+) Show first 5 Terms

Phenotype

Phenotype resulting from sotalol

Phenotype where environments contain sotalol

Phenotype modified by environments containing sotalol

Human Disease / Model Data

Citations