maraviroc

Term ID

CHEBI:63608

Synonyms

4,4-difluoro-N-{(1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
maraviroc
maravirocum

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: azabicycloalkane monocarboxylic acid amide organofluorine compound triazoles

azabicycloalkane monocarboxylic acid amide organofluorine compound triazoles Show first 5 Terms
has_role: antiviral drug chemokine receptor 5 antagonist HIV fusion inhibitor

antiviral drug chemokine receptor 5 antagonist HIV fusion inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from maraviroc

Phenotype where environments contain maraviroc

Phenotype modified by environments containing maraviroc

Human Disease / Model Data

Citations