(S)-fenfluramine hydrochloride

Term ID

CHEBI:59730

Synonyms

• (+)-(S)-N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride
• (+)-fenfluramine hydrochloride
• (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine hydrochloride
• (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-aminium chloride
• dexfenfluramine HCl
• dexfenfluramine hydrochloride
• dextrofenfluramine hydrochloride

Definition

The hydrochloride salt of (S)-fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike the racemate it does not possess catecholamine agonist activity. It was formerly given by mouth in the treatment of obesity, but, like the racemate, was withdrawn wolrdwide following reports of valvular heart defects.

References

• Beilstein:7114728
• Beilstein:8165762
• CAS:3239-45-0
• DrugBank:DB01191
• KEGG:D03713

Ontology

ChEBI  ( EBI )