Search Ontology:
ChEBI
fosinopril
- Term ID
- CHEBI:5163
- Synonyms
-
- (2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
- (2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
- (4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline
- (S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
- Fosinopril
- Definition
- A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.
- References
-
- Beilstein:8176492
- CAS:98048-97-6
- DrugBank:DB00492
- KEGG:C07016
- KEGG:D07992
- LINCS:LSM-6485
- PMID:11937741
- PMID:18209565
- PMID:22729889
- PMID:8285178
- PMID:9195116
- Patent:CN101367839
- Patent:EP2264039
- Patent:US2010297711
- Patent:US4337201
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
-
- has_functional_parent
-
- has_role
-
- inverse is_conjugate_base_of
-
- is_conjugate_acid_of
-
Show first 5 Terms
Phenotype
Phenotype resulting from fosinopril
Phenotype where environments contain fosinopril
Phenotype modified by environments containing fosinopril
Human Disease / Model Data
Citations