alvocidib

Term ID

CHEBI:47344

Synonyms

(-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one
alvocidib
alvocidibum
Flavopiridol
HMR 1274
HMR-1274
L 86-8275
L 868275
L-868275
L86-8275

Definition

A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: dihydroxyflavone hydroxypiperidine monochlorobenzenes tertiary amino compound

dihydroxyflavone hydroxypiperidine monochlorobenzenes tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent antirheumatic drug apoptosis inducer EC 2.7.11.22 (cyclin-dependent kinase) inhibitor

antineoplastic agent antirheumatic drug apoptosis inducer EC 2.7.11.22 (cyclin-dependent kinase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: alvocidib(1+)

alvocidib(1+) Show first 5 Terms
is_conjugate_base_of: alvocidib(1+)

alvocidib(1+) Show first 5 Terms

Phenotype

Phenotype resulting from alvocidib

Phenotype where environments contain alvocidib

Phenotype modified by environments containing alvocidib

Human Disease / Model Data

Citations