NS 1619

Term ID

CHEBI:34879

Synonyms

• 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
• 1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazolone
• 1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
• 5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazole
• NS-1619
• NS1619

Definition

A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

References

• CAS:153587-01-0
• KEGG:C13833
• LINCS:LSM-3206
• PMID:15543339
• PMID:18706395
• PMID:21415309
• PMID:21441626
• PMID:24398773
• PMID:24497961
• PMID:24813114
• PMID:7534190
• PMID:7589189
• PMID:9151934
• Reaxys:8165035

Ontology

ChEBI  ( EBI )

Resources

CTD