epalrestat

Term ID

CHEBI:31539

Synonyms

• 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
• 5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
• epalrestat
• epalrestatum
• Kinedak
• ONO 2
• Ono 2235
• ONO-2
• ONO-2235
• {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid

Definition

A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.

References

• CAS:82159-09-9
• Drug_Central:1021
• KEGG:D01688
• PDBeChem:EPR
• PMID:19716319
• PMID:22820572
• PMID:23426701
• PMID:24363998
• PMID:3025043
• Patent:EP47109
• Patent:US4464382
• Reaxys:4236712
• Wikipedia:Epalrestat

Ontology

ChEBI  ( EBI )

Resources

CTD