Search Ontology:
ChEBI

doxifluridine

Term ID
CHEBI:31521
Synonyms
  • 1-(beta-D-5-desoxyribofuranoxyl)-5-fluoruracil
  • 5'-deoxy-5-fluorouridine
  • 5'-DFUR
  • 5'-dFUrd
  • 5-fluoro-5'-deoxyuridine
  • doxifluridina
  • Doxifluridine
  • doxifluridinum
  • Furtulon
  • Ro 21-9738
  • Ro 219738
Definition
A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from doxifluridine
Phenotype where environments contain doxifluridine
Phenotype modified by environments containing doxifluridine
Human Disease / Model Data
Citations
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