edrophonium

Term ID

CHEBI:251408

Synonyms

• (3-hydroxyphenyl)dimethylethylammonium
• 3-hydroxy-N,N-dimethyl-N-ethylanilinium
• edrophonium
• EDROPHONIUM ION
• Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium
• N-ethyl-3-hydroxy-N,N-dimethylanilinium
• N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium

Definition

A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.

References

• Beilstein:3905622
• CAS:312-48-1
• DrugBank:DB01010
• Drug_Central:988
• KEGG:C06976
• LINCS:LSM-5867
• PDBeChem:EDR
• PMID:7488499

Ontology

ChEBI  ( EBI )

Resources

CTD