Search Ontology:
ChEBI

SHP099

Term ID
CHEBI:234265
Synonyms
  • 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine
  • 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
  • SHP 099
  • SHP-099
Definition
A member of the class of pyrazines that is pyrazine substituted by amino, 2,3-dichlorophenyl, and 4-amino-4-methylpiperidin-1-yl groups at positions 2, 3, and 6, respectively. It is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, and 2.896 muM for SHP2, SHP2(D61Y), SHP2(E69K), SHP2(A72V), and SHP2(E76K).
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from SHP099
Phenotype where environments contain SHP099
Phenotype modified by environments containing SHP099
Phenotype affecting SHP099
Human Disease Model
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