CT-179

Term ID

CHEBI:234076

Synonyms

1-(2-(3-(3,4-dichlorophenyl)ureido)-6-methyl-pyrimidin-4-yl)-amino-3(dimethylamino)propane
1-(3,4-dichlorophenyl)-3-(4-{[3-(dimethylamino)propyl]amino}-6-methylpyrimidin-2-yl)urea
CT 179
CT179
N-(3,4-dichlorophenyl)-N'-(4-{[3-(dimethylamino)propyl]amino}-6-methylpyrimidin-2-yl)urea

Definition

A member of the class of pyridines that is pyridine substituted by [(3,4-dichlorophenyl)carbamoyl]amino, [3-(dimethylamino)propyl]amino, and methyl groups at positions 2, 4 and 6, respectively. It is a small molecule inhibitor of OLIG2 developed by Curtana Pharmaceuticals for the treatment of glioblastoma, medulloblastoma, and other brain cancers.

References

CAS:1996636-69-1
DrugBank:DB17114
PMCID:PMC5464075
PMCID:PMC5691953
PMCID:PMC5692999
PMCID:PMC6011959
PMCID:PMC6012181
PMCID:PMC6216246
PMCID:PMC6216824
PMCID:PMC8168211
PMID:35736214
PMID:39904981
PMID:39904987
Patent:WO2016138479

Ontology

ChEBI ( EBI )

Relationships

is a type of: dichlorobenzene phenylureas pyridines secondary amino compound tertiary amino compound

dichlorobenzene phenylureas pyridines secondary amino compound tertiary amino compound Show first 5 Terms
has_role: antineoplastic agent OLIG2 inhibitor

antineoplastic agent OLIG2 inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from CT-179

Phenotype where environments contain CT-179

Phenotype modified by environments containing CT-179

Phenotype affecting CT-179

Human Disease Model