flumatinib

Term ID

CHEBI:233593

Synonyms

4-[(4-methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-3-pyridinyl]-3-(trifluoromethyl)-benzamide
4-[(4-methylpiperazin-1-yl)methyl]-N-(6-methyl-5-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}pyridin-3-yl)-3-(trifluoromethyl)benzamide
flumbatinib
flumbatinibum
HH-GV-678
HH-GV678
HHGV 678
HHGV678

Definition

A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 2-methyl-N³-[4-(pyridin-3-yl)pyrimidin-2-yl]pyridine-3,5-diamine. It is an inhibitor of the non-receptor tyrosine kinase Bcr-Abl (IC₅₀ = 1.2 nM) and has been approved in China for the treatment of chronic myeloid leukaemia.

References

cas:895519-90-1
chemspider:25069687
drugbank:DB11904
pmc:PMC10428240
pmc:PMC9429059
pubmed:20703259
pubmed:32757049
pubmed:32797767
pubmed:36164408
pubmed:36619491
pubmed:36814813
pubmed:37006972
pubmed:37138411
pubmed:37214433
pubmed:37214442
pubmed:37551470
pubmed:38049316
pubmed:38387893
pubmed:38443260
pubmed:38461040
pubmed:38660838
pubmed:38692191
pubmed:38934064
pubmed:38992279
pubmed:39046364
pubmed:39134501
pubmed:39145083
pubmed:39296080
pubmed:39323606
pubmed:39735596
pubmed:39743250
pubmed:39816491
pubmed:39818454

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from flumatinib

Phenotype where environments contain flumatinib

Phenotype modified by environments containing flumatinib

Phenotype affecting flumatinib

Human Disease Model