zipalertinib

Term ID

CHEBI:233402

Synonyms

(S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido(5,4-b)indolizin-8-yl)acrylamide
CLN 081
CLN-081
CLN081
N-[(8S)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide
TAS 6417
TAS-6417
TAS6417
TPC 064
TPC-064
TPC064
zipalertinib
zipalertinibum

Definition

A member of the class of acrylamides that is (8S)-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizine-4,8-diamine in which the amino group at position 8S is substituted by an acryloyl group. It a covalent epidermal growth factor receptor inhibitor that targets exon 20 insertion mutations.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: acrylamides aromatic amine organic heterotricyclic compound primary amino compound quinolines ... Show All 6 Terms

acrylamides aromatic amine organic heterotricyclic compound primary amino compound quinolines secondary carboxamide Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer epidermal growth factor receptor antagonist

antineoplastic agent apoptosis inducer epidermal growth factor receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from zipalertinib

Phenotype where environments contain zipalertinib

Phenotype modified by environments containing zipalertinib

Phenotype affecting zipalertinib

Human Disease Model