EVP4593

Term ID

CHEBI:232358

Synonyms

• 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
• 6-amino-4-(4-phenoxyphenylethylamino)quinazoline
• 6-amino-4-[2-(4-phenoxyphenyl)ethylamino]quinazoline
• AG-F-89549
• CAY 10470
• CAY-10470
• CAY10470
• EVP 4593
• EVP-4593
• N(4)-(4-phenoxyphenethyl)quinazoline-4,6-diamine
• N(4)-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine
• N(4)-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
• QNZ

Definition

A member of the class of quinazolines that is quinazoline substituted by [2-(4-phenoxyphenyl)ethyl]amino and amino groups at positions 4 and 6, respectively. It is an inhibitor of NF-κB signal transduction pathway and exhibits protective effects in oncology, cardiovascular disease and parasite invasion.

References

• cas:545380-34-5
• hmdb:HMDB0246942
• lincs.smallmolecule:LSM-45149
• pubmed:21700213
• pubmed:28000898
• pubmed:28302490
• pubmed:28693192
• pubmed:30108783
• pubmed:30194168
• pubmed:30638515
• pubmed:30704052
• pubmed:31055008
• pubmed:32432727
• pubmed:34564023
• pubmed:34722891
• pubmed:35871734
• pubmed:36349549
• pubmed:36552336
• pubmed:36555369
• pubmed:36805135
• pubmed:37175413
• pubmed:37179969
• pubmed:37256224
• pubmed:38095503
• pubmed:39120322
• pubmed:39268468
• reaxys:9350957

Ontology

ChEBI  ( EBI )